Mtb ATP synthase-IN-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Mtb ATP synthase-IN-1 (compound 6ab) 是一种有效的 结核分枝杆菌 (Mtb) ATP 合成抑制剂，对 Mtb 的 MIC 为 0.452 ~ 0.499 μg/mL。Mtb ATP synthase-IN-1 代谢稳定性好，细胞毒性低 (Vero IC50 > 64 μg/mL)，具有一定的口服生物利用度。Mtb ATP synthase-IN-1 可用于抗结核分枝杆菌的研究。

Mtb ATP synthase-IN-1 (compound 6ab) is a potent Mycobacterium tuberculosis (Mtb) ATP synthase inhibitor, with MIC of 0.452-0.499 μg/mL against Mtb. Mtb ATP synthase-IN-1 has good metabolic stability, low cytotoxicity (Vero IC50 > 64 μg/mL), and acceptable oral bioavailability. Mtb ATP synthase-IN-1 can be used for researching anti-mycobacterium.

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Mtb ATP synthase-IN-1 (50 mg/kg for PO, 5 mg/kg for IV; single dosage) exhibits good metabolic stability and acceptable oral bioavailability.Pharmacokinetic Parameters of Mtb ATP synthase-IN-1 in male CD-1 mouse.Animal Model:Male CD-1 mouseDosage:50 and 5 mg/kg Administration:50 mg/kg for PO, 5 mg/kg for IV; single dosage (Pharmacokinetics Analysis) Result:Exhibited good metabolic stability and acceptable oral bioavailability.

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Endocrinology/Hormones

ATPase

ATPase

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2642394-38-3

323.3

C17H13N3O4

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 125 mg/mL (386.64 mM; 超声助溶 )

O=C1C(=O)C(NCC2=NC=CC=C2)=C1NC3=CC=C4OCOC4=C3

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(-20℃)

With Ice Pack

≥ 2 years